Synthesis of [beta]-ketomacrolides via 1-oxa[n]meta-cyclophanes and a new route to (+-)-patulolide C.

• Other Authors: Fong, Sun.
• Format: Others
• Language: English
• Published: Chinese University of Hong Kong 1994
• Subjects: Cyclophanes > Synthesis; Macrocyclic compounds > Synthesis
• Online Access: http://library.cuhk.edu.hk/record=b5895379; http://repository.lib.cuhk.edu.hk/en/item/cuhk-318133

by Fong Sun. === On t.p., "+" appears over "-". === Thesis (M.Phil.)--Chinese University of Hong Kong, 1994. === Includes bibliographical references (leaves 41-43). === Acknowledgements --- p.i === Contents --- p.ii === Abstract --- p.iii === Abbreviations --- p.iv === Chapter I --- Introduction === Chapter I-1 --- General background --- p.1 === Chapter I-2 --- Literature survey --- p.3 === Chapter I-2-1 --- Ley's approach to β-ketomacrolides --- p.3 === Chapter I-2-2 --- Weiler's approach to β-ketomacrolides --- p.4 === Chapter I-2-3 --- Macrocyclic β-ketomacrolides formation through sulfide contraction ´ؤIreland's approach --- p.5 === Chapter II --- Result and Discussion === Chapter II-1 --- General strategy for the synthesis of 1 -oxa[n]metacyclophanes --- p.7 === Chapter II-2 --- l-Oxa[n]metacyclophanes as masked β-ketomacrolides synthons --- p.9 === Chapter II-3 --- Application to the synthesis of natural products --- p.10 === Chapter II-4 --- An alternate approach for the synthesis of (2E)-2-dodecen-l 1-olide´ؤA structural proof --- p.15 === Chapter III --- Conclusion --- p.17 === Chapter IV --- Experimental --- p.18 === Chapter V --- References --- p.41 === Chapter VI --- Spectra --- p.44