Investigation on the Read-through Phenomenon of Pre-mature Stop Codons
有一件對於研究生物學的學術人士最正常的事情是當核糖體負責翻譯識別任何三種終止密碼子,一個釋放因子結合核酶和釋放的同時結束翻譯的增長的肽鏈上。但是最令人驚奇的是居然會有實驗發現,這種終止密碼子的終止進程也有可能會被提前抑制,而且被翻譯成氨基酸。在另一方面,無意義抑制傳送核糖核酸被發現及被證明能夠蛋白翻譯過程中把特殊氨基酸摻入正在增長的肽鏈上。第21 種氨基酸,硒半胱胺酸,是這些能被摻入的修飾氨基酸中的其中一個,它是專門通過無意義抑制傳送核糖核酸識別UGA 終止密碼子進行。除了這個發現外,第22種氨基酸吡咯賴胺酸,也已被證明能利用無意義抑制傳送核糖核酸和傳送核糖核酸合成酶來直接摻入正在增長的肽鏈上...
Other Authors: | Wong Wai Hung (author.) |
---|---|
Format: | Others |
Language: | English Chinese |
Published: |
2017
|
Subjects: | |
Online Access: | http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292327 |
Similar Items
-
Selection for tandem stop codons in ciliate species with reassigned stop codons.
by: Ira Fleming, et al.
Published: (2019-01-01) -
Stop-codon read-through arises largely from molecular errors and is generally nonadaptive.
by: Chuan Li, et al.
Published: (2019-05-01) -
Lactate dehydrogenase is C-terminally extended by stop codon read-through which targets this isoform into the peroxisomes
by: George, Rosemol
Published: (2016) -
Stop codons in bacteria are not selectively equivalent
by: Povolotskaya Inna S, et al.
Published: (2012-09-01) -
Stops making sense: translational trade-offs and stop codon reassignment
by: Elgar Greg S, et al.
Published: (2011-07-01)