Systems Biology Approaches to The Study of Neurological Disorders and Somatic Cell Reprogramming
This thesis describes the development of an systems biology method to study transcriptional programs that are activated during early and late phases of cell-fusion mediated reprogramming, as well as an implementation of systems-level analysis using reverse-engineered regulatory networks to study CNS...
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2016
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| Online Access: | https://doi.org/10.7916/D8CR5TV2 |
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ndltd-columbia.edu-oai-academiccommons.columbia.edu-10.7916-D8CR5TV22019-05-09T15:15:17ZSystems Biology Approaches to The Study of Neurological Disorders and Somatic Cell ReprogrammingShin, William Kihoon2016ThesesCell hybridizationCentral nervous system--DiseasesNervous system--DegenerationGenetic transcriptionBioinformaticsNeurosciencesBiology--ClassificationThis thesis describes the development of an systems biology method to study transcriptional programs that are activated during early and late phases of cell-fusion mediated reprogramming, as well as an implementation of systems-level analysis using reverse-engineered regulatory networks to study CNS disorders like Alcohol Addiction, and neurodegenerative disorders like Alzheimer's Disease (AD), and Parkinson's Disease (PD). The results will show an unprecedented view into the mechanisms underlying complex processes and diseases, and will demonstrate the predictive power of these methodologies that extended far beyond their original contexts.Englishhttps://doi.org/10.7916/D8CR5TV2 |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Cell hybridization Central nervous system--Diseases Nervous system--Degeneration Genetic transcription Bioinformatics Neurosciences Biology--Classification |
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Cell hybridization Central nervous system--Diseases Nervous system--Degeneration Genetic transcription Bioinformatics Neurosciences Biology--Classification Shin, William Kihoon Systems Biology Approaches to The Study of Neurological Disorders and Somatic Cell Reprogramming |
| description |
This thesis describes the development of an systems biology method to study transcriptional programs that are activated during early and late phases of cell-fusion mediated reprogramming, as well as an implementation of systems-level analysis using reverse-engineered regulatory networks to study CNS disorders like Alcohol Addiction, and neurodegenerative disorders like Alzheimer's Disease (AD), and Parkinson's Disease (PD). The results will show an unprecedented view into the mechanisms underlying complex processes and diseases, and will demonstrate the predictive power of these methodologies that extended far beyond their original contexts. |
| author |
Shin, William Kihoon |
| author_facet |
Shin, William Kihoon |
| author_sort |
Shin, William Kihoon |
| title |
Systems Biology Approaches to The Study of Neurological Disorders and Somatic Cell Reprogramming |
| title_short |
Systems Biology Approaches to The Study of Neurological Disorders and Somatic Cell Reprogramming |
| title_full |
Systems Biology Approaches to The Study of Neurological Disorders and Somatic Cell Reprogramming |
| title_fullStr |
Systems Biology Approaches to The Study of Neurological Disorders and Somatic Cell Reprogramming |
| title_full_unstemmed |
Systems Biology Approaches to The Study of Neurological Disorders and Somatic Cell Reprogramming |
| title_sort |
systems biology approaches to the study of neurological disorders and somatic cell reprogramming |
| publishDate |
2016 |
| url |
https://doi.org/10.7916/D8CR5TV2 |
| work_keys_str_mv |
AT shinwilliamkihoon systemsbiologyapproachestothestudyofneurologicaldisordersandsomaticcellreprogramming |
| _version_ |
1719046642727911424 |