Apolipoprotein E and Mitochondria-associated Endoplasmic Reticulum Membrane Dysfunction
Despite the tremendous advances of the last century, the cause of Alzheimer disease (AD) remains unclear. Genetic analysis of families with Alzheimer disease has revealed a disease-associated variant of the APOE gene, which encodes apolipoprotein E, a transporter of lipids in the blood and central n...
Main Author: | Tambini, Marc D. |
---|---|
Language: | English |
Published: |
2015
|
Subjects: | |
Online Access: | https://doi.org/10.7916/D84M9484 |
Similar Items
-
Role of endoplasmic reticulum calcium signaling in the pathogenesis of Alzheimer disease
by: Elena ePopugaeva, et al.
Published: (2013-09-01) -
Presenilin mutations deregulate mitochondrial Ca2+ homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans
by: Shaarika Sarasija, et al.
Published: (2018-07-01) -
Disruption of endoplasmic reticulum-mitochondria tethering proteins in post-mortem Alzheimer's disease brain
by: Dawn H.W. Lau, et al.
Published: (2020-09-01) -
Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease
by: Juan Garrido-Maraver, et al.
Published: (2020-01-01) -
Unfolded protein stress in the endoplasmic reticulum and mitochondria: a role in neurodegeneration
by: Sebastián eBernales, et al.
Published: (2012-04-01)