Biochemical and Single Molecule Studies of Backbone Branched RNAs and Lariat Debranching Enzyme
The intronic lariat RNA generated during pre-mRNA splicing includes a branch-point adenosine residue that is linked through the 2'-O position to the 5'-end of the RNA sequence. This 2'-5'-phosphodiester linkage in the lariat RNA backbone is cleaved (debranched) by the lariat debr...
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| Format: | Others |
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Research Showcase @ CMU
2016
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| Online Access: | http://repository.cmu.edu/dissertations/1042 http://repository.cmu.edu/cgi/viewcontent.cgi?article=2081&context=dissertations |