Design, synthesis and testing of β-strand mimics as protease inhibitors
Chapter 1 gives background information on proteases and discusses the concept of protease inhibition as a therapeutic strategy for humans. It introduces the key concept that conformation defines biological activity. It also outlines how proteases almost universally bind their substrate/inhibitors in...
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| Language: | en |
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University of Canterbury. Chemistry
2009
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| Online Access: | http://hdl.handle.net/10092/1984 |