Whole genome doubling confers unique genetic vulnerabilities on tumors
Whole genome doubling (WGD) occurs early in tumorigenesis and generates genetically unstable tetraploid cells that fuel tumor development. Cells that undergo WGD (WGD+) must adapt to accommodate their abnormal tetraploid state; however, the nature of these adaptations, and whether they confer vulner...
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| Language: | en_US |
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2021
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| Online Access: | https://hdl.handle.net/2144/42054 |