Brain cell injury: metabolic dysfunction in ischemia and hypoxia

• Main Author: Salvadore, Christopher P.
• Language: en_US
• Published: Boston University 2019
• Online Access: https://hdl.handle.net/2144/38099

Thesis (M.A.)--Boston University === PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [e-mail]. Thank you. === A sequence of biochemical events responsible for the destruction of brain cells during oxygen deprivation has been proposed based on available experimental evidence reviewed in the text. Oxygen deficiency results in a diminished p02 within the cell, resulting in inhibition of the electron transport chain and depletion of ATP pools. The decrease in cellular energy charge mediates a reduction in phospholipid synthesis, as well as the collapse of ionic gradients across the plasma and organelle membranes. Highly elevated levels of cytosolic Ca++ follow, activating membrane bound phospholipases which progressively deplete the membrane of its phospholipids. Membrane structure becomes severely compromised, resulting in loss of function. Cell death ensues. === 2031-01-01