High-throughput drug screen to identify compounds working selectively and synergistically with CQ to inhibit proliferation of TSC-2 deficient cells
Tuberous sclerosis complex (TSC) is a multisystem genetic disease that is caused by a germ line mutation in the genes TSC1 and TSC2. Patients with the disease tend to suffer from benign tumors of the brain, heart, kidneys, skin, and other organs that contain giant cells. Although mTORC1 inhibitors (...
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| Language: | en_US |
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2019
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| Online Access: | https://hdl.handle.net/2144/36637 |