The role of Jade-1 in DNA mismatch damage and repair in renal cancer
The von Hippel-Lindau (VHL) tumor suppressor pVHL is lost in 90% of clear-cell renal-cell carcinomas (ccRCCs). Jade-1 is a renal tumor suppressor that is normally stabilized by pVHL. MutS Homolog2 (MSH2) is a key initiator in DNA mismatch repair (MMR). Defects in MMR are associated with genome-wide...
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| Language: | en_US |
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2016
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| Online Access: | https://hdl.handle.net/2144/17041 |