Studies toward the mechanism of allosteric activation in phenylalanine hydroxylase
Phenylalanine hydroxylase (PAH, EC: 1.14.16.1) is a non-heme iron tetrahydropterin-dependent monooxygenase that maintains phenylalanine (L-Phe) homeostasis via conversion of L-Phe to L-Tyr. PAH is an allosteric enzyme that converts from an inactive T-state to an active R-state upon addition of subst...
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| Language: | en_US |
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2016
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| Online Access: | https://hdl.handle.net/2144/14146 |