The application of intramolecular N-acyliminium cyclisation strategies towards biologically active heterocycles
We describe the application of N-acyliminium cyclisation strategies to access a range of heterocycles with potential for biological activity. We have described an asymmetric approach towards the anti-tumour pyrroloisoquinoline alkaloid (R)-(+)-crispine A. We have achieved a synthesis of the pyrrolo[...
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Loughborough University
2011
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ndltd-bl.uk-oai-ethos.bl.uk-7634012019-02-12T03:23:48ZThe application of intramolecular N-acyliminium cyclisation strategies towards biologically active heterocyclesTowler, Joannah M. R.2011We describe the application of N-acyliminium cyclisation strategies to access a range of heterocycles with potential for biological activity. We have described an asymmetric approach towards the anti-tumour pyrroloisoquinoline alkaloid (R)-(+)-crispine A. We have achieved a synthesis of the pyrrolo[2,1-a]benzazepine template which is a sub-unit of the Homoerythrina alkaloids, and the functionalised dodecahydrobenz[a]indolo[3,2-h]quinolizine template, which is a sub-unit of the manadomanzamine alkaloids. In addition, we have described an asymmetric synthesis of the α-hydrazino pyrroloisoquinoline ring system, towards the synthesis of conformationally restricted peptidomimetics.Loughborough Universityhttps://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.763401https://dspace.lboro.ac.uk/2134/9113Electronic Thesis or Dissertation |
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NDLTD |
| description |
We describe the application of N-acyliminium cyclisation strategies to access a range of heterocycles with potential for biological activity. We have described an asymmetric approach towards the anti-tumour pyrroloisoquinoline alkaloid (R)-(+)-crispine A. We have achieved a synthesis of the pyrrolo[2,1-a]benzazepine template which is a sub-unit of the Homoerythrina alkaloids, and the functionalised dodecahydrobenz[a]indolo[3,2-h]quinolizine template, which is a sub-unit of the manadomanzamine alkaloids. In addition, we have described an asymmetric synthesis of the α-hydrazino pyrroloisoquinoline ring system, towards the synthesis of conformationally restricted peptidomimetics. |
| author |
Towler, Joannah M. R. |
| spellingShingle |
Towler, Joannah M. R. The application of intramolecular N-acyliminium cyclisation strategies towards biologically active heterocycles |
| author_facet |
Towler, Joannah M. R. |
| author_sort |
Towler, Joannah M. R. |
| title |
The application of intramolecular N-acyliminium cyclisation strategies towards biologically active heterocycles |
| title_short |
The application of intramolecular N-acyliminium cyclisation strategies towards biologically active heterocycles |
| title_full |
The application of intramolecular N-acyliminium cyclisation strategies towards biologically active heterocycles |
| title_fullStr |
The application of intramolecular N-acyliminium cyclisation strategies towards biologically active heterocycles |
| title_full_unstemmed |
The application of intramolecular N-acyliminium cyclisation strategies towards biologically active heterocycles |
| title_sort |
application of intramolecular n-acyliminium cyclisation strategies towards biologically active heterocycles |
| publisher |
Loughborough University |
| publishDate |
2011 |
| url |
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.763401 |
| work_keys_str_mv |
AT towlerjoannahmr theapplicationofintramolecularnacyliminiumcyclisationstrategiestowardsbiologicallyactiveheterocycles AT towlerjoannahmr applicationofintramolecularnacyliminiumcyclisationstrategiestowardsbiologicallyactiveheterocycles |
| _version_ |
1718975515559198720 |