CTLA-4-mediated trans-endocytosis in the control of T cell co-stimulation

CTLA-4-mediated trans-endocytosis in the control of T cell co-stimulation

The signal threshold for the activation of a naïve T cell upon recognising its antigen is regulated tightly by the CD28/CTLA-4 - CD80/86 pathway. Within this framework, CTLA-4 has been shown to limit the availability of co-stimulation by physical removal of CD80 and CD86 from the APC, via the mecha...

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Bibliographic Details
Main Author:	Ovcinnikovs, Vitalijs
Published:	University College London (University of London) 2018
Online Access:	https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.763253

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