The role of oncogenic RAC1 in melanoma initiation and progression

The role of oncogenic RAC1 in melanoma initiation and progression

RAC1P29S is the third most common mutation in human melanoma, after oncogenic BRAF and NRAS mutations. Here, we study the role of RAC1P29S in melanoma initiation and progression. Signalling studies and functional screening reveal that RAC1P29S activates PAK, AKT and the SRF/MRTF transcription factor...

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Bibliographic Details
Main Author:	Lionarons, Daniël Andreas
Published:	University College London (University of London) 2018
Online Access:	https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.763221

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