The role of oncogenic RAC1 in melanoma initiation and progression
RAC1P29S is the third most common mutation in human melanoma, after oncogenic BRAF and NRAS mutations. Here, we study the role of RAC1P29S in melanoma initiation and progression. Signalling studies and functional screening reveal that RAC1P29S activates PAK, AKT and the SRF/MRTF transcription factor...
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University College London (University of London)
2018
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.763221 |