Utilising FcRn trafficking and a novel bispecific antibody to enhance antigen clearance
Conventional therapeutic immunoglobulin G (IgG) antibodies bind to antigen with high affinity and specificity and have a long serum half-life. The long half-life is due to the pH-dependent protection of IgG from lysosomal degradation, by the neonatal Fc receptor, FcRn. Although capable of neutralisi...
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University of Bath
2018
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761042 |