Studies in isoquinoline chemistry
The use of Reissert compounds as intermediates for the synthesis of 1-benzylisoquinolines has been investigated. An improved method, utilising sodium hydride, for the generation of the carbanion of Reissert compounds and subsequent reaction with benzyl halides has been found and demonstrated to be a...
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Loughborough University
1968
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756387 |
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ndltd-bl.uk-oai-ethos.bl.uk-7563872018-11-08T03:20:56ZStudies in isoquinoline chemistryKershaw, J. R.1968The use of Reissert compounds as intermediates for the synthesis of 1-benzylisoquinolines has been investigated. An improved method, utilising sodium hydride, for the generation of the carbanion of Reissert compounds and subsequent reaction with benzyl halides has been found and demonstrated to be a general procedure. This method has been successfully applied as the key stage in providing a new total synthesis of the alkaloid petaline. The stereochemistry of the Reissert compound system has been elucidated by spectroscopic techniques.Loughborough Universityhttps://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756387https://dspace.lboro.ac.uk/2134/34427Electronic Thesis or Dissertation |
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NDLTD |
| description |
The use of Reissert compounds as intermediates for the synthesis of 1-benzylisoquinolines has been investigated. An improved method, utilising sodium hydride, for the generation of the carbanion of Reissert compounds and subsequent reaction with benzyl halides has been found and demonstrated to be a general procedure. This method has been successfully applied as the key stage in providing a new total synthesis of the alkaloid petaline. The stereochemistry of the Reissert compound system has been elucidated by spectroscopic techniques. |
| author |
Kershaw, J. R. |
| spellingShingle |
Kershaw, J. R. Studies in isoquinoline chemistry |
| author_facet |
Kershaw, J. R. |
| author_sort |
Kershaw, J. R. |
| title |
Studies in isoquinoline chemistry |
| title_short |
Studies in isoquinoline chemistry |
| title_full |
Studies in isoquinoline chemistry |
| title_fullStr |
Studies in isoquinoline chemistry |
| title_full_unstemmed |
Studies in isoquinoline chemistry |
| title_sort |
studies in isoquinoline chemistry |
| publisher |
Loughborough University |
| publishDate |
1968 |
| url |
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756387 |
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AT kershawjr studiesinisoquinolinechemistry |
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