Evaluation of CD8+ T-cell numbers and repertoires

Evaluation of CD8+ T-cell numbers and repertoires

This thesis tackles the problem of T-cell receptor (TCR) diversity, from two different points of view. On one hand, the observed TCR diversity is studied from a mathematical perspective, concentrating on the probability of a sample to reproduce a certain percentage of the total TCR diversity. On the...

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Main Author: Ferrarini, Marco
Other Authors: Lythe, Grant ; Molina-Paris, Carmen
Published: University of Leeds 2018
Subjects:
519
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.755129
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spelling ndltd-bl.uk-oai-ethos.bl.uk-7551292019-03-05T15:48:14ZEvaluation of CD8+ T-cell numbers and repertoiresFerrarini, MarcoLythe, Grant ; Molina-Paris, Carmen2018This thesis tackles the problem of T-cell receptor (TCR) diversity, from two different points of view. On one hand, the observed TCR diversity is studied from a mathematical perspective, concentrating on the probability of a sample to reproduce a certain percentage of the total TCR diversity. On the other hand, biological samples are considered, focusing on statistical analysis of the observed VDJ gene segments. To conclude, a stochastic model is developed to explore the population dynamics of a simulated TCR repertoire. Computer simulations complete this multidisciplinary approach, helping verifying the different mathematical theories behind the stochastic models.519University of Leedshttps://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.755129http://etheses.whiterose.ac.uk/21520/Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 519
spellingShingle 519
Ferrarini, Marco
Evaluation of CD8+ T-cell numbers and repertoires
description This thesis tackles the problem of T-cell receptor (TCR) diversity, from two different points of view. On one hand, the observed TCR diversity is studied from a mathematical perspective, concentrating on the probability of a sample to reproduce a certain percentage of the total TCR diversity. On the other hand, biological samples are considered, focusing on statistical analysis of the observed VDJ gene segments. To conclude, a stochastic model is developed to explore the population dynamics of a simulated TCR repertoire. Computer simulations complete this multidisciplinary approach, helping verifying the different mathematical theories behind the stochastic models.
author2 Lythe, Grant ; Molina-Paris, Carmen
author_facet Lythe, Grant ; Molina-Paris, Carmen
Ferrarini, Marco
author Ferrarini, Marco
author_sort Ferrarini, Marco
title Evaluation of CD8+ T-cell numbers and repertoires
title_short Evaluation of CD8+ T-cell numbers and repertoires
title_full Evaluation of CD8+ T-cell numbers and repertoires
title_fullStr Evaluation of CD8+ T-cell numbers and repertoires
title_full_unstemmed Evaluation of CD8+ T-cell numbers and repertoires
title_sort evaluation of cd8+ t-cell numbers and repertoires
publisher University of Leeds
publishDate 2018
url https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.755129
work_keys_str_mv AT ferrarinimarco evaluationofcd8tcellnumbersandrepertoires
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