Developing a model of mitochondrial heteroplasmy in human pluripotent stem cell-derived cardiomyoctes
Hypertrophic cardiomyopathy and arrhythmias are common in patients with heteroplasmic mtDNA mutations but their pathogenesis and how the levels of mutation change in patients over time remain poorly understood. Therefore, a robust in vitro model of heteroplasmy in cardiomyocytes (CMs) is currently n...
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Imperial College London
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.754716 |