Next-generation sequencing identifies mechanisms of tumourigenesis caused by loss of SMARCB1 in Malignant Rhabdoid Tumours

Next-generation sequencing identifies mechanisms of tumourigenesis caused by loss of SMARCB1 in Malignant Rhabdoid Tumours

Introduction: Malignant Rhabdoid Tumours (MRT) are unique malignancies caused by biallelic inactivation of a single gene (SMARCB1). SMARCB1 encodes for a protein that is part of the SWI/SNF chromatin remodelling complex, responsible for the regulation of hundreds of downstream genes/pathways. Despit...

Full description

Bibliographic Details
Main Author:	Finetti, Martina Anna
Published:	University of Newcastle upon Tyne 2015
Online Access:	https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748112

Similar Items

Malignant rhabdoid tumor of the kidney in an adult with loss of INI1 expression and mutation in the SMARCB1 gene
by: Eunkyung Han, et al.
Published: (2021-03-01)

The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation
by: Zhi-Yan Han, et al.
Published: (2016-01-01)

The significance of SMARCB1 in the pathogenesis of renal cell carcinoma with rhabdoid features
by: Yi-Wen Wang, et al.
Published: (2021-10-01)

Global Chromatin Changes Resulting from Single-Gene Inactivation—The Role of SMARCB1 in Malignant Rhabdoid Tumor
by: Colin Kenny, et al.
Published: (2021-05-01)

Germline nonsense-mutations of the SMARCB1 gene in Russian patients with rhabdoid renal tumors
by: D. S. Mikhaylenko, et al.
Published: (2017-06-01)

Timing of Smarcb1 and Nf2 inactivation determines schwannoma versus rhabdoid tumor development
by: Jeremie Vitte, et al.
Published: (2017-08-01)

Malignant rhabdoid tumour of the liver: A case report
by: Muni Varma, et al.
Published: (2021-02-01)

Dissecting genetic pathways in schwannomatosis and malignant rhabdoid tumour
by: Algar E
Published: (2012-04-01)

Malignant Extra Renal Rhabdoid Tumour Presenting as Central Airway Obstruction
by: Karan Madan, et al.
Published: (2014-01-01)

SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression
by: Tara T. Doucet-O’Hare, et al.
Published: (2021-06-01)

Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours
by: Lars Custers, et al.
Published: (2021-03-01)

Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors.
by: Elizabeth M Algar, et al.
Published: (2009-01-01)

SMARCB1- and vimentin-positive esophageal carcinoma with undifferentiated components, rhabdoid features, and a good prognosis: a case report
by: Hideki Nagano, et al.
Published: (2019-01-01)

Malignant rhabdoid tumor of liver
by: Sandeep Agarwala, et al.
Published: (2014-01-01)

An Infrequent Adenosarcoma Mimicking other Uterine Rhabdoid Tumours
by: B Archana, et al.
Published: (2021-03-01)

Cutaneous malignant rhabdoid tumor in the palm of an adult
by: Masaki Fujioka, et al.
Published: (2013-07-01)

Apoptotic response of malignant rhabdoid tumor cells
by: Nocentini Silvano
Published: (2003-07-01)

Rhabdoid meningioma: A rare malignant subtype
by: Sri Ganesh, K, et al.
Published: (2011)

Identification of candidate genes for devil facial tumour disease tumourigenesis
by: Robyn L. Taylor, et al.
Published: (2017-08-01)

Systemic muscle wasting and coordinated tumour response drive tumourigenesis
by: Holly Newton, et al.
Published: (2020-09-01)

Next generation sequencing to identify new genetic causes of familial craniosynostosis
by: Hashimoto, Akiko
Published: (2017)

Rhabdoid Tumour of Kidney with Metastasis to Ovary – A Rare Presentation
by: Chhanda Das, et al.
Published: (2016-01-01)

Surgery and Actinomycin Improve Survival in Malignant Rhabdoid Tumor
by: Ryan Horazdovsky, et al.
Published: (2013-01-01)

Malignant rhabdoid tumour of the liver in a seven-month-old female infant: A case report and literature review
by: Matthew G Martelli, et al.
Published: (2013-01-01)

Rapid detection of SMARCB1 sequence variation using high resolution melting
by: Ashley David M, et al.
Published: (2009-12-01)

The Progress of Next Generation Sequencing in the Assessment of Myeloid Malignancies
by: Fulya Öz Puyan, et al.
Published: (2019-03-01)

Congenital presentation of synchronous Atypical Teratoid Rhabdoid Tumor and Malignant Rhabdoid Tumor of the urinary bladder in a term infant
by: Vivian Tang, et al.
Published: (2021-08-01)

Atypical teratoid/ rhabdoid tumour in adult - A rare case report
by: Pratap Reddy, et al.
Published: (2014-04-01)

Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition
by: Andrew L Hong, et al.
Published: (2019-03-01)

High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors
by: Céline Chauvin, et al.
Published: (2017-11-01)

The role of the kallikrein-kinin system in prostate and breast tumourigenesis and tumour-associated angiogenesis..
by: Wright, Jaclyn.
Published: (2011)

Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors
by: Jocelyn P. Wong, et al.
Published: (2016-10-01)

Malignant rhabdoid tumor—The great mimicker: Two case reports
by: Dasic Ivana, MD, et al.
Published: (2021-04-01)

Case Analysis of 14 Children with Malignant Rhabdoid Tumor of the Kidney
by: Li J, et al.
Published: (2021-06-01)

MUTATIONS OF THE SMARCB1 GENE IN HUMAN CANCERS
by: D. S. Mikhaylenko, et al.
Published: (2017-01-01)

Inhibition of MYC by the SMARCB1 tumor suppressor
by: April M. Weissmiller, et al.
Published: (2019-05-01)

The Utility of Next-Generation Sequencing for Identifying the Genetic Basis of Dementia
by: Aleksandra Klimkowicz-Mrowiec, et al.
Published: (2021-08-01)

Identifying novel genetic causes for hereditary myopathies: from conventional approaches to next-generation sequencing
by: Jorge Manuel dos Santos Marques de Oliveira
Published: (2020)

The Feasibility of Metagenomic Next-Generation Sequencing to Identify Pathogens Causing Tuberculous Meningitis in Cerebrospinal Fluid
by: Shengnan Wang, et al.
Published: (2019-09-01)

Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1.
by: Edwin Choy, et al.
Published: (2014-01-01)