Contribution of a genetic variant of the Wnt receptor LRP6 to synapse vulnerability in the ageing hippocampus

Contribution of a genetic variant of the Wnt receptor LRP6 to synapse vulnerability in the ageing hippocampus

Synapse dysfunction and loss represent key pathological hallmarks of Alzheimer's disease (AD). Wnt signalling, in particular through the Wnt co-receptor LRP6, has a critical role in maintaining the structural and functional integrity of synaptic connections in the adult brain. LRP6 dysfunction...

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Bibliographic Details
Main Author:	Buechler, Johanna Daniela
Published:	University College London (University of London) 2018
Subjects:	570
Online Access:	https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.747311

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