The modification of insulin for therapeutic purposes
First this thesis outlines the historical background and current status of diabetes therapeutics. This includes prolonged action preparations, oral hypoglycaemic agents, approaches to peroral insulin therapy and methods of insulin modification, with emphasis on derivatives of clinical interest. Then...
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University of Oxford
1978
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ndltd-bl.uk-oai-ethos.bl.uk-7306312018-04-04T03:10:45ZThe modification of insulin for therapeutic purposesMoore, Roger Randall1978First this thesis outlines the historical background and current status of diabetes therapeutics. This includes prolonged action preparations, oral hypoglycaemic agents, approaches to peroral insulin therapy and methods of insulin modification, with emphasis on derivatives of clinical interest. Then the analytical methods are described. These include a novel method, using chromatography on silica-gel loaded paper, for analysing the state of acylation of water-insoluble insulin derivites. The next two chapters describe the synthesis of the acyl hydroxysuccinimidyl esters and the protected insulin derivites, followed by the coupling, purification and analysis of the products.University of Oxfordhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730631https://ora.ox.ac.uk/objects/uuid:594d3fd8-f638-4257-9ee7-480b8550d298Electronic Thesis or Dissertation |
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NDLTD |
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NDLTD |
| description |
First this thesis outlines the historical background and current status of diabetes therapeutics. This includes prolonged action preparations, oral hypoglycaemic agents, approaches to peroral insulin therapy and methods of insulin modification, with emphasis on derivatives of clinical interest. Then the analytical methods are described. These include a novel method, using chromatography on silica-gel loaded paper, for analysing the state of acylation of water-insoluble insulin derivites. The next two chapters describe the synthesis of the acyl hydroxysuccinimidyl esters and the protected insulin derivites, followed by the coupling, purification and analysis of the products. |
| author |
Moore, Roger Randall |
| spellingShingle |
Moore, Roger Randall The modification of insulin for therapeutic purposes |
| author_facet |
Moore, Roger Randall |
| author_sort |
Moore, Roger Randall |
| title |
The modification of insulin for therapeutic purposes |
| title_short |
The modification of insulin for therapeutic purposes |
| title_full |
The modification of insulin for therapeutic purposes |
| title_fullStr |
The modification of insulin for therapeutic purposes |
| title_full_unstemmed |
The modification of insulin for therapeutic purposes |
| title_sort |
modification of insulin for therapeutic purposes |
| publisher |
University of Oxford |
| publishDate |
1978 |
| url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730631 |
| work_keys_str_mv |
AT moorerogerrandall themodificationofinsulinfortherapeuticpurposes AT moorerogerrandall modificationofinsulinfortherapeuticpurposes |
| _version_ |
1718618112774897664 |