Synthesis and evaluation of cationic lipids for gene delivery
This thesis entails the synthesis and in vitro evaluation of a number of cationic lipids. These lipids include those with a dimethylamine (DMA) headgroup or trimethylamine (TMA) headgroup, a seven or eleven carbon chain length or a mixed carbon chain length within the hydrophobic domain. The lipids...
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Queen's University Belfast
2017
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ndltd-bl.uk-oai-ethos.bl.uk-7275112017-12-24T16:54:21ZSynthesis and evaluation of cationic lipids for gene deliveryMaginty, Amanda Bronagh2017This thesis entails the synthesis and in vitro evaluation of a number of cationic lipids. These lipids include those with a dimethylamine (DMA) headgroup or trimethylamine (TMA) headgroup, a seven or eleven carbon chain length or a mixed carbon chain length within the hydrophobic domain. The lipids are characterised by acyclic or macrocyclic hydrophobic regions that are either saturated or unsaturated. The work describes the successful synthetic routes to these various different cationic lipids and looks at the biological effects that are had on toxicity, transfection and DNA binding, when the various different structural aspects of the cationic lipids are changed.616Queen's University Belfasthttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727511Electronic Thesis or Dissertation |
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616 |
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616 Maginty, Amanda Bronagh Synthesis and evaluation of cationic lipids for gene delivery |
| description |
This thesis entails the synthesis and in vitro evaluation of a number of cationic lipids. These lipids include those with a dimethylamine (DMA) headgroup or trimethylamine (TMA) headgroup, a seven or eleven carbon chain length or a mixed carbon chain length within the hydrophobic domain. The lipids are characterised by acyclic or macrocyclic hydrophobic regions that are either saturated or unsaturated. The work describes the successful synthetic routes to these various different cationic lipids and looks at the biological effects that are had on toxicity, transfection and DNA binding, when the various different structural aspects of the cationic lipids are changed. |
| author |
Maginty, Amanda Bronagh |
| author_facet |
Maginty, Amanda Bronagh |
| author_sort |
Maginty, Amanda Bronagh |
| title |
Synthesis and evaluation of cationic lipids for gene delivery |
| title_short |
Synthesis and evaluation of cationic lipids for gene delivery |
| title_full |
Synthesis and evaluation of cationic lipids for gene delivery |
| title_fullStr |
Synthesis and evaluation of cationic lipids for gene delivery |
| title_full_unstemmed |
Synthesis and evaluation of cationic lipids for gene delivery |
| title_sort |
synthesis and evaluation of cationic lipids for gene delivery |
| publisher |
Queen's University Belfast |
| publishDate |
2017 |
| url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727511 |
| work_keys_str_mv |
AT magintyamandabronagh synthesisandevaluationofcationiclipidsforgenedelivery |
| _version_ |
1718580575871172608 |