Chemoenzymatic synthesis of isotopically labelled folates
Dihydrofolate reductase (DHFR) is a key enzyme in cellular anabolism. It catalyses the reduction of 7,8-dihydrofolate (H2F) to 5,6,7,8-tetrahydrofolate (H4F) via hydride transfer from the C4 position of NADPH to the C6 position of H2F accompanied with protonation at the N5 position of H2F. Due to th...
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Cardiff University
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.725711 |