HSP70 as a target for correction of Wilson disease causing ATP7B mutants

Copper (Cu) is an essential micronutrient, which operates as a cofactor of enzymes regulating a wide range of critical physiological processes. However, Cu overload compromises the redox balance in cells and tissues causing serious toxicity. Removal of excess Cu from the body is driven be Cu-transpo...

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Bibliographic Details
Main Author: Concilli, Mafalda
Published: Open University 2017
Subjects:
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.724873