New methods for the arylation of trivalent phosphorus species, and, Studies towards the synthesis of sesqui-lignan natural products

New methods for the arylation of trivalent phosphorus species, and, Studies towards the synthesis of sesqui-lignan natural products

Chapter one describes two efficient synthesis methods for the preparation of functionalised phosphonium salts. The first method utilises aryl radicals generated by a photo-induced decomposition of diaryliodonium salts, with the second method generating aryl radicals from arylboronic acids and mangan...

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Main Author: Fearnley, Adam
Published: University of Nottingham 2017
Subjects:
547
QD241 Organic chemistry
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.719614
id ndltd-bl.uk-oai-ethos.bl.uk-719614
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spelling ndltd-bl.uk-oai-ethos.bl.uk-7196142018-11-27T03:20:34ZNew methods for the arylation of trivalent phosphorus species, and, Studies towards the synthesis of sesqui-lignan natural productsFearnley, Adam2017Chapter one describes two efficient synthesis methods for the preparation of functionalised phosphonium salts. The first method utilises aryl radicals generated by a photo-induced decomposition of diaryliodonium salts, with the second method generating aryl radicals from arylboronic acids and manganese acetate. In both cases a broad substrate scope is demonstrated with respect to both the phosphorus and arylating species. Chapter two describes approaches to the total synthesis of plant sesqui-neolignans. The synthesis of macranthol was achieved in 5 steps from commercially available 4-allylanisole in 7% yield. As well as the first synthesis of the core [4.3.0] ring structure of the fargenin/fargenone family of natural products.547QD241 Organic chemistryUniversity of Nottinghamhttps://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.719614http://eprints.nottingham.ac.uk/42420/Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 547
QD241 Organic chemistry
spellingShingle 547
QD241 Organic chemistry
Fearnley, Adam
New methods for the arylation of trivalent phosphorus species, and, Studies towards the synthesis of sesqui-lignan natural products
description Chapter one describes two efficient synthesis methods for the preparation of functionalised phosphonium salts. The first method utilises aryl radicals generated by a photo-induced decomposition of diaryliodonium salts, with the second method generating aryl radicals from arylboronic acids and manganese acetate. In both cases a broad substrate scope is demonstrated with respect to both the phosphorus and arylating species. Chapter two describes approaches to the total synthesis of plant sesqui-neolignans. The synthesis of macranthol was achieved in 5 steps from commercially available 4-allylanisole in 7% yield. As well as the first synthesis of the core [4.3.0] ring structure of the fargenin/fargenone family of natural products.
author Fearnley, Adam
author_facet Fearnley, Adam
author_sort Fearnley, Adam
title New methods for the arylation of trivalent phosphorus species, and, Studies towards the synthesis of sesqui-lignan natural products
title_short New methods for the arylation of trivalent phosphorus species, and, Studies towards the synthesis of sesqui-lignan natural products
title_full New methods for the arylation of trivalent phosphorus species, and, Studies towards the synthesis of sesqui-lignan natural products
title_fullStr New methods for the arylation of trivalent phosphorus species, and, Studies towards the synthesis of sesqui-lignan natural products
title_full_unstemmed New methods for the arylation of trivalent phosphorus species, and, Studies towards the synthesis of sesqui-lignan natural products
title_sort new methods for the arylation of trivalent phosphorus species, and, studies towards the synthesis of sesqui-lignan natural products
publisher University of Nottingham
publishDate 2017
url https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.719614
work_keys_str_mv AT fearnleyadam newmethodsforthearylationoftrivalentphosphorusspeciesandstudiestowardsthesynthesisofsesquilignannaturalproducts
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