Investigation of the thermoinstability of cystic fibrosis mutants
Cystic fibrosis (CF) is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel. The most common CF mutation F508del produces a misfolded protein with three major defects: reduced protein processing; aberrant channel gating and thermo-instability. Low-temp...
| Main Author: | |
|---|---|
| Published: |
University of Bristol
2015
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702448 |