The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents

The design, synthesis and optimisation of phosphoinositide-3-kinase (PI3K) inhibitors as potential anti-inflammatory agents

Phosphoinositide-3-kinases (PI3Ks) are a family of lipid kinases which control a wide range of intracellular pathways implicated in inflammatory respiratory diseases. In this thesis, the optimisation of two chemical templates, (i) a pyridone series, and (ii) an aminopyrimidine series, is described,...

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Bibliographic Details
Main Author:	Hardy, Charlotte
Published:	University of Strathclyde 2016
Online Access:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701547

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