The synthesis of biologically active guanidines
Several new alkyl (147, 161 and 167) and alkoxy-methyl derivatives (171, 175) were prepared as analogues of the anti-tumour agent tirapazamine (38). These were prepared in an attempt to couple them to the pro-drug delivery agent 52. The bicyclic guanidine natural product monalidine A (186) was prepa...
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Bangor University
2016
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.698936 |
| Summary: | Several new alkyl (147, 161 and 167) and alkoxy-methyl derivatives (171, 175) were prepared as analogues of the anti-tumour agent tirapazamine (38). These were prepared in an attempt to couple them to the pro-drug delivery agent 52. The bicyclic guanidine natural product monalidine A (186) was prepared as its hydrochloride salt from 2-undecanone via a novel 3-step synthesis. The biological activity of monalidine A (186) and one of its synthetic precursors were evaluated against Leishmaniasis infantum and Trypanosoma cruzi. Research towards the total synthesis of the tricyclic arbusculidine A (187) from cucumber aldehyde is reported. |
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