An investigation into the cellular expression of genes involved in resistance to aflatoxin B1, and the mode of cell death elicited by this carcinogen, in a model system using AFB1-resistant and AFB1-sensitive rat hepatocyte cell lines
The toxicity of aflatoxin B1 (AFB1), has been extensively studied in the rat, and its carcinogenic effects have been well documented. Binding of the cytochrome P-450-activated exo-8,9-epoxide form of the molecule to DNA and protein to form adducts, forms the basis of the xenobiotic's cytotoxici...
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University of Leicester
2000
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696739 |