The design, synthesis and evaluation of novel inhibitors and activity-based probes targeting serine proteases in cystic fibrosis
Cystic Fibrosis (CF) is a genetic disorder primarily characterised by chronic infection and inflammation within the lungs. Serine proteases, in particular trypsin-Ilke serine proteases are associated with dehydration of the airways through proteolytiC activation of the Epithelial Sodium Channel (ENa...
| Main Author: | |
|---|---|
| Published: |
Queen's University Belfast
2015
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695337 |