Structure elucidation of the kalimantacin antibiotics

In this thesis the production, isolation and purification of the kalimantacin antibiotics are described along with details of the elucidation of the structures including the relative and absolute stereochemistry. Kalimantacin A, isolated from Pseudomonas jluorescens strain BCCM_ ID9359, is biosynthe...

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Main Author:	Thistlethwaite, Iain R. G.
Published:	University of Bristol 2015
Subjects:	615.1
Online Access:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685333

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spelling	ndltd-bl.uk-oai-ethos.bl.uk-6853332017-03-16T16:23:30ZStructure elucidation of the kalimantacin antibioticsThistlethwaite, Iain R. G.2015In this thesis the production, isolation and purification of the kalimantacin antibiotics are described along with details of the elucidation of the structures including the relative and absolute stereochemistry. Kalimantacin A, isolated from Pseudomonas jluorescens strain BCCM_ ID9359, is biosynthesised by a trans-AT type I polyketide synthase (PKS) and exhibits strong and selective activity against multi-resistant Staphylococcus aureus (MRSA). Two mutant strains, ~batF and ~batM, have been produced from which 17- hydroxy analogue 20, 27-descarbamoyl analogue 21 and 17-hydroxy-27-descarbamoyl analogue 22 were isolated and fully characterised.615.1University of Bristolhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685333Electronic Thesis or Dissertation
collection	NDLTD
sources	NDLTD
topic	615.1
spellingShingle	615.1 Thistlethwaite, Iain R. G. Structure elucidation of the kalimantacin antibiotics
description	In this thesis the production, isolation and purification of the kalimantacin antibiotics are described along with details of the elucidation of the structures including the relative and absolute stereochemistry. Kalimantacin A, isolated from Pseudomonas jluorescens strain BCCM_ ID9359, is biosynthesised by a trans-AT type I polyketide synthase (PKS) and exhibits strong and selective activity against multi-resistant Staphylococcus aureus (MRSA). Two mutant strains, ~batF and ~batM, have been produced from which 17- hydroxy analogue 20, 27-descarbamoyl analogue 21 and 17-hydroxy-27-descarbamoyl analogue 22 were isolated and fully characterised.
author	Thistlethwaite, Iain R. G.
author_facet	Thistlethwaite, Iain R. G.
author_sort	Thistlethwaite, Iain R. G.
title	Structure elucidation of the kalimantacin antibiotics
title_short	Structure elucidation of the kalimantacin antibiotics
title_full	Structure elucidation of the kalimantacin antibiotics
title_fullStr	Structure elucidation of the kalimantacin antibiotics
title_full_unstemmed	Structure elucidation of the kalimantacin antibiotics
title_sort	structure elucidation of the kalimantacin antibiotics
publisher	University of Bristol
publishDate	2015
url	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685333
work_keys_str_mv	AT thistlethwaiteiainrg structureelucidationofthekalimantacinantibiotics
_version_	1718423034815053824

Structure elucidation of the kalimantacin antibiotics

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