The importance of uncoupling troponin I phosphorylation from Ca2+ sensitivity in the pathogenesis of cardiomyopathy
Heart muscle contraction is regulated via the β adrenergic response that results to phosphorylation of Protein Kinase A (PKA), which in turn decreases the Ca2+ sensitivity of the cardiac myofilament, which is very important for the heart muscle to relax. Mutations in the thin filament that cause Dil...
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Imperial College London
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.682087 |