Low shear stress promotes atherosclerosis through activation of EndMT

Introduction: Atherosclerosis is influenced by local blood flow patterns that exert wall shear stress (WSS) on endothelial cells (EC). Low, oscillatory WSS promotes atherosclerosis by influencing EC dysfunction (inflammation, permeability and proliferation), while high WSS is athero-protective. A re...

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Bibliographic Details
Main Author: Mahmoud, Marwa
Other Authors: Evans, Paul C.
Published: University of Sheffield 2015
Subjects:
610
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678102