Biomarker screening tools to improve the control and prevention of endemic Bovine Respiratory Disease (BRD)

• Main Author: Gray, D. W. E.
• Published: Queen's University Belfast 2014
• Subjects: 636.2
• Online Access: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.676489

Bovine Parainfluenza Virus-3 (BPIV-3) is a major viral pathogen of the Bovine Respiratory Disease (BRD) complex, which is considered to be one of the most significant causes of economic loss in intensively reared cattle worldwide. Current diagnostic tests for BPIV -3 infection provide limited information on the health status of infected animals. This study was designed to address major limitations in BRD management, using Bovine Parainfleunza Virus-3 (BPIV -3) as a model virus to investigate whether screening tools based on biomarkers could be employed to successfully aid in the identification of infected animals and to understand the processes of successful immune response to vaccination. Through the application of in vitro and in vivo biomarker screening tools, this study demonstrated the potential for proteomic and metabolomics marker screening approaches to provide more accurate diagnosis of BPIV -3 infected animals and assess immune responses at the metabolite level. The application of these markers to diagnostic testing could provide numerous benefits for the management of BPIV -3 infection at the herd level. This research highlights the potential for metabolomic and proteomic biomarker approaches to be applied to the improved management and diagnosis of agricultural diseases.