Investigating the significance of 11β-HSD type 1 in the ageing brain

In-situ-hybridisation of the mouse hippocampus and cerebellum, showed no changes in 11β-HSD1 mRNA with ageing. However, decreases in mRNA of corticosteroid receptors indicated a possible, neuro-protective mechanisms through changes in GC signalling. The improved ageing in a hippocampal –dependent be...

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Bibliographic Details
Main Author: Hibberd, Carina Jayne
Published: University of Edinburgh 2005
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.652411