Engineering T cells to overcome the hostile tumour microenvironment
Adoptive immunotherapy with autologous T lymphocytes transduced with anti-tumour antigen-specific T cell receptors (TCRs) has emerged as a promising anti-cancer therapy. In vitro studies have suggested that T cell function may be limited by tumour associated macrophages (TAMs) and myeloid-derived su...
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University College London (University of London)
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.647284 |