New bis-alkylation reagents for protein conjugation
Bis-alkylation for disulfide-bridging PEGylation has emerged as a valid strategy for protein conjugation. Proteins can be efficiently modified to add a three-carbon methylene bridge between the two sulfurs in a disulfide bond. The so-called C3 bis-sulfone reagent is a linear poly (ethylene glycol) (...
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University College London (University of London)
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.647251 |