Multi-scale modelling of allostery in protein homodimers

Allostery is a form of signalling within biomolecules such that ligand binding to a protein affects its activity at a second site. Allostery was described by early models to be driven by structural changes in the protein. However, more recently there has been increasing evidence that dynamics can co...

Full description

Bibliographic Details
Main Author: Burnell, David
Published: Durham University 2015
Subjects:
540
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.646429