Targeting of the PI3K/AKT/mTOR pathway in human prostate cancer

Targeting of the PI3K/AKT/mTOR pathway in human prostate cancer

The tumour suppressor PTEN is frequently lost in advanced prostate cancer leading to over-activation of the PI3K/AKT/mTOR pathway. Therefore targeting of the PI3K signalling with pathway-specific inhibitors has been proposed as a therapeutic strategy. Inhibition of AKT and mTOR kinases in prostate c...

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Bibliographic Details
Main Author: Butler, Dominika Ewelina
Other Authors: Maitland, Norman J. ; Davies, Barry R.
Published: University of York 2014
Subjects:
570
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.643655

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