Synthesis and biological evaluation of novel anti-tumour (E)-styrylsulfonyl methylpyridines

Synthesis and biological evaluation of novel anti-tumour (E)-styrylsulfonyl methylpyridines

ON01910.Na (Rigosertib, Estybon®), a styryl benzylsulfone, is a Phase III stage anti-cancer agent. This non-ATP competitive kinase inhibitor has multi-targeted activity, promoting mitotic arrest and apoptosis. Extensive Phase I/II studies with ON01910.Na, conducted in patients with solid tumours and...

Full description

Bibliographic Details
Main Author:	Lu, Tiangong
Published:	University of Nottingham 2014
Subjects:	616.99 RS Pharmacy and materia medica
Online Access:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639916

Similar Items

Molecular expression of recombinant Apoptin in planta and preliminary evaluation of biological characteristics of plant-made Apoptin on cancerous cells
by: Chan, Xiao Ying
Published: (2017)

Structural modification of Clusianone from Garcinia parvifolia and in vitro evaluation targeting microtubule system of respiratory carcinoma
by: Nagalingam, Sree Vaneesa
Published: (2017)

Cardamonin induces apoptosis in human nasopharyngeal carcinoma cells via mitochondrial death pathway mediated by caspase-3 and caspase-8 activation, independent of caspase-9 signalling responses
by: Chiang, Michelle
Published: (2016)

Organogels for intratumoural delivery
by: Mohamed, Masar Basim Mohsin
Published: (2017)

Computer-aided design and synthesis of novel anti-DENV nucleoside analogues
by: Cima, Cecilia
Published: (2017)

Novel functionalized polymers for nanoparticle formulations with anti cancer drugs
by: Puri, Sanyogitta
Published: (2007)

Design, synthesis and biological evaluation of novel antitumour compounds
by: Kadri, Hachemi
Published: (2010)

Biological and clinical evaluation of intensity modulated radiotherapy for brain tumours
by: Sivabalasingham, S.
Published: (2016)

Disabling factors mediating anti-tumour cytotoxic T lymphocyte suppression and tumour progression
by: Basingab, Fatemah Salem
Published: (2016)

Development and evaluation of novel susceptibility MRI biomarkers of tumour vascular structure and function
by: Burrell, Jake Samuel
Published: (2011)

Biological properties and clinical relevance of disseminated tumour cells in patients with hepatocellular carcinoma
by: Battula, Narendra Reddy
Published: (2014)

Studies on IL-15 mediated anti-tumour immune responses in prostate cancer
by: Sakellariou, Christina Alexandra
Published: (2017)

Construction and characterisation of anti-tumour antibody-based proteins for use in diagnostics and therapeutics
by: Paton, Lois
Published: (2016)

Novel approaches for targeting BRCA2-deficient tumour cells
by: Tacconi, Eliana Maria Cristina
Published: (2015)

Investigating the adverse effects of novel tumour-specific IAP antagonists
by: Hayward, Giles Mortimer
Published: (2017)

Synthesis and biological evaluation of a novel HPMA copolymer conjugate-based combination therapy designed for the treatment of breast cancer
by: Greco, Francesca
Published: (2006)

Circulating tumour cells and biomarkers in neuroendocrine tumours
by: Khan, M. S.
Published: (2013)

Molecular expression and immunotherapeutic potential of the novel tumour associated antigen T21
by: Malhi, S. K.
Published: (2013)

Screening for novel brain tumour initiation mechanisms at single cell resolution
by: Jaworek, Karolina
Published: (2016)

Unlocking the potential of novel taxa : a study on Actinoallomurus
by: Cruz, João Carlos Santos
Published: (2016)

Importance of the tumour microenvironment in the treatment response of prostate tumours
by: Byrne, Niall Maurice
Published: (2014)

Development of functional micelles from biodegradable amphiphilic block copolymers for drug delivery and tumour therapy
by: Gulfam, Muhammad
Published: (2017)

microRNA expression in colorectal tumours : identification of novel mechanisms of gene regulation
by: Amankwatia, Edward Bobie
Published: (2014)

Studies of the Wilms' tumour 1 gene in patients with solid tumours
by: Gillmore, Roopinder
Published: (2006)

The response of tumour-infiltrating myeloid cells to the chemotherapy-treatment of tumours
by: Harwood, Reuben
Published: (2013)

Understanding the role of the solid tumour microenvironment in brain tumour progression
by: Richards, R.
Published: (2017)

Novel imaging techniques for intraoperative assessment of tumour resection margins in breast-conserving surgery
by: Grootendorst, Maarten Ruben
Published: (2017)

On desmoid tumours and their aetiology
by: Mouat, Thomas Bernard
Published: (1912)

The design, synthesis and evaluation of novel cyclohexadienones as cancer chemopreventive agents
by: Jones, G. W.
Published: (2014)

Novel radioimmunotherapy for lymphoma and solid tumours both as a single agent and in combination with the vascular disrupting agents
by: Dancey, G. S.
Published: (2011)

Analysis of the tumour microenvironment in CLL
by: Hamilton, Emma
Published: (2013)

Allogenic tumour vaccines for melanoma
by: Kayaga, Justina
Published: (2000)

The experimental production of adenomyomatous tumours
by: Hunter, J. W. A.
Published: (1932)

Stochastic modelling of tumour growth
by: Sahoo, Anita
Published: (2008)

Retroviral targeting to tumour antigens
by: Chowdhury, S.
Published: (2004)

Notes on uterine fibroid tumours
by: Pollard, George Herbert
Published: (1890)

Experimental studies on the origin of cells in grafted tumours, with a consideration of the role of viruses in tumour growth
by: Croft, C. J.
Published: (1972)

Evaluation of copper-64-ATSM for non-invasive imaging of tumour hypoxia by positron emission
by: Wood, K. A.
Published: (2009)

Discovery and evaluation of anti-cancer agents
by: Lam, Fong Ki
Published: (2010)

Are Generic Anti-infectives Effective?
by: Paraidathathu, Thomas
Published: (2012)