Discovery of BACE-1 inhibitors using an integrated computational and experimental approach

There are numerous complementary approaches to facilitate the identification of novel inhibitors for biological targets, including high throughput screening and fragment-based drug discovery. Computational tools are often employed to predict binding pose and affinity of the new inhibitors. In this t...

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Bibliographic Details
Main Author: Magnatti, Giorgia
Other Authors: Nelson, A. ; Fishwick, C. ; Hooper, N.
Published: University of Leeds 2014
Subjects:
540
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638938