Copper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperones
Copper has an important role in the life cycle of many streptomycetes, stimulating the developmental switch between vegetative mycelium and aerial hyphae concomitant with the production of antibiotics. In streptomycetes a gene encoding for a putative Sco-like protein has been identified and is part...
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University of Essex
2014
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.635891 |
| Summary: | Copper has an important role in the life cycle of many streptomycetes, stimulating the developmental switch between vegetative mycelium and aerial hyphae concomitant with the production of antibiotics. In streptomycetes a gene encoding for a putative Sco-like protein has been identified and is part of an operon that contains two other genes predicted to handle cellular copper. This thesis reports first on the Sco-like protein from Streptomyces lividans (Sco sl) and presents a series of experiments that firmly establish a role for Sco sl as a copper metallochaperone as opposed to a role as a thiol-disulfide oxidoreductase that has been assigned to other bacterial Sco proteins. |
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