Gain-of-function STAT1 mutations impair STAT3 function and underlie susceptibility to Chronic Mucocutaneous Candidiasis
Background: Signal transducer and activator of transcription (STAT)3 activation triggers transcription of interleukin (IL)-17 which is crucial for mounting protective immune responses against fungi. Several mutations affecting the STAT3/IL-17 pathway have been reported, resulting in selective suscep...
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University of Newcastle upon Tyne
2014
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.635004 |