Mechanistic studies of the amyloid precursor protein intracellular domain (AICO) with implications for Alzheimer's disease
Proteolytic cleavage of the amyloid precursor protein (APP) by the successive actions of [beta]- and [gamma] secretases produces amyloid-B-peptide (AB), the principal constituent of plaques in Alzheimer's disease (AD). In AD research, therapeutic strategies have heavily focussed on modifying th...
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University of Leeds
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634749 |