Replication stress links structural and numerical chromosomal instability in colorectal cancer
Chromosomal instability (CIN), describing an increased rate of numerical and structural chromosome aberrations, is a principal driver of inter-cellular genetic heterogeneity in tumours. CIN is widely observed in solid malignancies, and is associated with poor patient outcome and drug resistance. Des...
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University College London (University of London)
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626067 |