The role of gephyrin, collybistin and novel GEFs in the synaptic clustering of inhibitory receptors
GABAA and glycine receptors are clustered at inhibitory synapses via interactions with the scaffolding protein gephyrin. In turn, gephyrin is translocated to synapses by collybistin, a guanine nucleotide exchange factor (GEF) for Cdc42. Mutations in the human collybistin gene (ARHGEF9) give rise to...
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University College London (University of London)
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625959 |