The emerging role of the α4(+)α4(-) interface as a determinant of functional signatures of α4ß2 nicotinic acetylcholine receptors
The α4β2 nicotinic acetylcholine receptor (nAChR) assembles in two alternate forms, (α4β2)₂α4 and (α4β2)₂β2, which display stoichiometry-specific agonist sensitivity. Being heteromeric pentameric ligand-gated ion channels (pLGIC), α4β2 receptors are activated by binding of agonist to sites located a...
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Oxford Brookes University
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616287 |