Regulation of structure-selective nucleases by the SLX4 scaffold in ICL repair and HJ resolution
Mammalian SLX4 is a scaffold protein that directs the formation of a multi-protein DNA processing toolkit that includes three different structure-selective endonucleases: XPF-ERCC1, MUS81-EME1 and SLX1. The SLX4 complex has been shown to have essential roles in repair of DNA interstrand crosslinks (...
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University of Dundee
2014
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613597 |