Purine-based Inhibitors of Nek2 Kinase

Purine-based Inhibitors of Nek2 Kinase

Protein kinases are involved in many important regulatory processes throughout the cell cycle. In particular, several kinase families (i.e. cyclin-dependent kinases, aurora, polo, Nek and checkpoint kinases) have been identified to play important roles in centrosome regulation and cell cycle progres...

Full description

Bibliographic Details
Main Author: Wong, Christopher
Published: University of Newcastle Upon Tyne 2010
Subjects:
615.19
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612618
id ndltd-bl.uk-oai-ethos.bl.uk-612618
record_format oai_dc
spelling ndltd-bl.uk-oai-ethos.bl.uk-6126182015-03-20T05:02:54ZPurine-based Inhibitors of Nek2 KinaseWong, Christopher2010Protein kinases are involved in many important regulatory processes throughout the cell cycle. In particular, several kinase families (i.e. cyclin-dependent kinases, aurora, polo, Nek and checkpoint kinases) have been identified to play important roles in centrosome regulation and cell cycle progression. Consistent errors in cell duplication can often result in defective cells, possessing aneuploidy and/ or chromosome instability (CIN); a common trait of cancer cells. Overexpression and increased kinase activity is often observed in a diverse number of human cancers. Numerous drug discovery programs targeting CDKs, aurora, Polo and Chk kinases are currently ongoing, with evidence of anti-tumour activity observed by using selective, small molecule inhibitors.615.19University of Newcastle Upon Tynehttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612618Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 615.19
spellingShingle 615.19
Wong, Christopher
Purine-based Inhibitors of Nek2 Kinase
description Protein kinases are involved in many important regulatory processes throughout the cell cycle. In particular, several kinase families (i.e. cyclin-dependent kinases, aurora, polo, Nek and checkpoint kinases) have been identified to play important roles in centrosome regulation and cell cycle progression. Consistent errors in cell duplication can often result in defective cells, possessing aneuploidy and/ or chromosome instability (CIN); a common trait of cancer cells. Overexpression and increased kinase activity is often observed in a diverse number of human cancers. Numerous drug discovery programs targeting CDKs, aurora, Polo and Chk kinases are currently ongoing, with evidence of anti-tumour activity observed by using selective, small molecule inhibitors.
author Wong, Christopher
author_facet Wong, Christopher
author_sort Wong, Christopher
title Purine-based Inhibitors of Nek2 Kinase
title_short Purine-based Inhibitors of Nek2 Kinase
title_full Purine-based Inhibitors of Nek2 Kinase
title_fullStr Purine-based Inhibitors of Nek2 Kinase
title_full_unstemmed Purine-based Inhibitors of Nek2 Kinase
title_sort purine-based inhibitors of nek2 kinase
publisher University of Newcastle Upon Tyne
publishDate 2010
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612618
work_keys_str_mv AT wongchristopher purinebasedinhibitorsofnek2kinase
_version_ 1716788713608970240

Similar Items